Before infecting humans, tick-borne bacteria or viruses first have to get past a tick’s defenses to colonize it. How this occurs is not well understood. To investigate, Yale researchers studied a model of the second-most-common tick-borne infection in the United States, human granulocytic anaplasmosis, which can cause headaches, muscle pain, and even death.
The researchers found that in ticks, the bacterium that causes the infection, A. phagocytophilum, triggers the expression of a particular protein. This protein alters molecules in the tick’s gut, allowing the bacteria to enter and colonize the gut microbes.
“It’s like a stealth warrior that indirectly changes the tick by using the tick’s own defense system,” said Dr. Erol Fikrig, chief of the Infectious Diseases Section at Yale School of Medicine and senior author of the study.
The unexpected finding could help scientists develop strategies to block A. phagocytophilum and other tick-borne agents that cause disease, say the researchers. Fikrig’s team will explore the phenomenon in the bacterium that causes Lyme disease, and its work could have implications for other mosquito-borne infections, such as Zika and West Nile.
The study was published by the Proceedings of the National Academy of Sciences.
Other authors are Nabil M. Abraham, Lei Liu, Brandon L. Jutras, Akhilesh K. Yadav, Sukanya Narasimhan, Vissagan Gopalakrishnan, Juliana M. Ansari, Kimberly K. Jefferson, Felipe Cava, and Christine Jacobs-Wagner.
This work was supported in part by a gift from the John Monsky and Jennifer Weis Monsky Lyme Disease Research Fund, by a National Institutes of Health grant, and by the Howard Hughes Medical Institute.
Source: Yale University